Endocrine Abstracts

Expression of the sodium iodide symporter (NIS) protein, and correct membrane insertion, is required for efficient iodide uptake in thyroid and lactating breast. Radioactive iodide is routinely utilized to target remnant thyroid and metastasis after total thyroidectomy for thyroid cancer. Stimulation of NIS expression by high levels of TSH, however, is necessary to achieve radioiodide uptake into thyroid cancer sufficient for therapy. The majority of breast cancer also express...